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KMID : 1149120200170010010
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Journal of the Korean Society for Psoriasis
2020 Volume.17 No. 1 p.10 ~ p.14
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Follicular lymphoma in a psoriasis patient treated with adalimumab followed by cyclosporine
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Bae Kyung-Nam
Ha Dae-Lyong
Son Jin-Hwa
Lee Jung-Soo
Shin Ki-Hyuk
Kim Hoon-Soo
Ko Hyun-Chang
Kim Moon-Bum
Kim Byung-Soo
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Abstract
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Biologics and conventional immunosuppressants are widely used for psoriasis. Among them, tumor necrosis factor-α inhibitors and cyclosporine are frequently implicated for moderate to severe plaque psoriasis. However, because of their immunoregulatory effect, both have been suspected to increase the risk of lymphomas, although each drug’s individual effect has never been definitively proven. Of course, little is known about the potential synergistic effect of them on the development of lymphoma.
A 47-year old man, previously diagnosed with psoriasis, was treated with adalimumab for 9 months and received cyclosporine for 6 months thereafter. Three months later, he developed dyspnea and weight loss. Laboratory exam showed markedly elevated white blood cells and multifocal lymphadenopathy and pleural effusion were revealed by imaging studies. Bone marrow and lymph node biopsy confirmed the diagnosis of follicular lymphoma.
Here, we report a case of follicular lymphoma in a patient with psoriasis treated with adalimumab followed by cyclosporine.
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KEYWORD
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Adalimumab, Cyclosporine, Lymphoma, Tumor necrosis factor-α inhibitor
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